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Spiro Getsios

Assistant Professor in Dermatology and Cell and Molecular Biology

Cells contact and communicate with their neighbors via specialized cell surface receptors. This intimate exchange of information controls morphogenetic events during embryonic development and maintains tissue organization in adults. Birth defects and cancer commonly result when cells fail to recognize and respond appropriately to their environment. The work in my laboratory is guided by the hypothesis that epithelial cells receive and interpret contextual information through the coordination of adhesion and signaling receptor systems present on the cell surface. To test this idea, we manipulate the ability of epithelial cells to interact with one another and measure their capacity to transduce intracellular signals that regulate cell fate and behavior. In parallel, we assess the potential of cell surface signaling receptors to alter the manner in which epithelial cells adhere to their partners. A three-dimensional in vitro model of the human epidermis is used to help define these adhesion-signaling networks during epithelial tissue morphogenesis.

Selected Publications

  • Dai J, Brooks Y, Lefort K, Getsios S, Dotto GP "The retinoid-related orphan receptor RORα promotes keratinocyte differentiation via FOXN1." PLoS One, 2013, 8(7) p. e70392.
    Summary | Full Text (PMC) | Full Text (DOI)

  • Gordon K, Kochkodan JJ, Blatt H, Lin SY, Kaplan N, Johnston A, Swindell WR, Hoover P, Schlosser BJ, Elder JT, Gudjonsson JE, Getsios S "Alteration of the EphA2/Ephrin-A signaling axis in psoriatic epidermis." J Invest Dermatol, 2013, 133(3) p. 712-22.
    Summary | Full Text (PMC) | Full Text (DOI)

  • Lin S, Gordon K, Kaplan N, Getsios S "Ligand targeting of EphA2 enhances keratinocyte adhesion and differentiation via desmoglein 1." Mol Biol Cell, 2010, 21(22) p. 3902-14.
    Summary | Full Text (PMC) | Full Text (DOI)

Address

  • Office: Ward 9-132

Contact

  • Telephone: (312) 695-8106
  • E-Mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
Spiro Getsios
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