Publications

2007

Astle J., Ferguson J., German J., Harrigan G., Kelleher N., Kodadek T., Parks B., Roth M., Singletary K., Wenger C., Mahady G. "Characterization of proteomic and metabolomic responses to dietary factors and supplements." J Nutr, 2007, 137 p. 2787-93
18029500
Whitteck J., Ni W., Griffin B., Eliot A., Thomas P., Kelleher N., Metcalf W., van der Donk W. "Reassignment of the structure of the antibiotic A53868 reveals an unusual amino dehydrophosphonic acid." Angew Chem Int Ed Engl, 2007, 46 p. 9089-92
17990255
Parks B., Jiang L., Thomas P., Wenger C., Roth M., Boyne M., Burke P., Kwast K., Kelleher N. "Top-down proteomics on a chromatographic time scale using linear ion trap fourier transform hybrid mass spectrometers." Anal Chem, 2007, 79 p. 7984-91
17915963
PMC2361135
Siuti N., Kelleher N. "Decoding protein modifications using top-down mass spectrometry." Nat Methods, 2007, 4 p. 817-21
17901871
PMC2365886
Hwang Y., Thompson P., Wang L., Jiang L., Kelleher N., Cole P. "A selective chemical probe for coenzyme A-requiring enzymes." Angew Chem Int Ed Engl, 2007, 46 p. 7621-4
17768748
Calderone C., Iwig D., Dorrestein P., Kelleher N., Walsh C. "Incorporation of nonmethyl branches by isoprenoid-like logic: multiple beta-alkylation events in the biosynthesis of myxovirescin A1." Chem Biol, 2007, 14 p. 835-46
17656320
PMC2084360

2006

Tran J., Doucette A. "Cyclic polyamide oligomers extracted from nylon 66 membrane filter disks as a source of contamination in liquid chromatography/mass spectrometry." J Am Soc Mass Spectrom, 2006, 17 p. 652-6
16517177
Ricardo A., Frye F., Carrigan M., Tipton J., Powell D., Benner S. "2-Hydroxymethylboronate as a reagent to detect carbohydrates: application to the analysis of the formose reaction." J Org Chem, 2006, 71 p. 9503-5
17137382
Dorrestein P., Blackhall J., Straight P., Fischbach M., Garneau-Tsodikova S., Edwards D., McLaughlin S., Lin M., Gerwick W., Kolter R., Walsh C., Kelleher N. "Activity screening of carrier domains within nonribosomal peptide synthetases using complex substrate mixtures and large molecule mass spectrometry." Biochemistry, 2006, 45 p. 1537-46
16460000
PMC2565507
Boyne M., Pesavento J., Mizzen C., Kelleher N. "Precise characterization of human histones in the H2A gene family by top down mass spectrometry." J Proteome Res, 2006, 5 p. 248-53
16457589
Thomas C., Kelleher N., Mizzen C. "Mass spectrometric characterization of human histone H3: a bird's eye view." J Proteome Res, 2006, 5 p. 240-7
16457588
Siuti N., Roth M., Mizzen C., Kelleher N., Pesavento J. "Gene-specific characterization of human histone H2B by electron capture dissociation." J Proteome Res, 2006, 5 p. 233-9
16457587
Miller L., Chatterjee C., van der Donk W., Kelleher N. "The dehydratase activity of lacticin 481 synthetase is highly processive." J Am Chem Soc, 2006, 128 p. 1420-1
16448091
PMC2532561
Du Y., Parks B., Sohn S., Kwast K., Kelleher N. "Top-down approaches for measuring expression ratios of intact yeast proteins using Fourier transform mass spectrometry." Anal Chem, 2006, 78 p. 686-94
16448040
Patrie S., Ferguson J., Robinson D., Whipple D., Rother M., Metcalf W., Kelleher N. "Top down mass spectrometry of < 60-kDa proteins from Methanosarcina acetivorans using quadrupole FRMS with automated octopole collisionally activated dissociation." Mol Cell Proteomics, 2006, 5 p. 14-25
16236702
Woodyer R., Shao Z., Thomas P., Kelleher N., Blodgett J., Metcalf W., van der Donk W., Zhao H. "Heterologous production of fosfomycin and identification of the minimal biosynthetic gene cluster." Chem Biol, 2006, 13 p. 1171-82
17113999
McClerren A., Cooper L., Quan C., Thomas P., Kelleher N., van der Donk W. "Discovery and in vitro biosynthesis of haloduracin, a two-component lantibiotic." Proc Natl Acad Sci U S A, 2006, 103 p. 17243-8
17085596
PMC1859917
Karanam B., Jiang L., Wang L., Kelleher N., Cole P. "Kinetic and mass spectrometric analysis of p300 histone acetyltransferase domain autoacetylation." J Biol Chem, 2006, 281 p. 40292-301
17065153
Dorrestein P., Bumpus S., Calderone C., Garneau-Tsodikova S., Aron Z., Straight P., Kolter R., Walsh C., Kelleher N. "Facile detection of acyl and peptidyl intermediates on thiotemplate carrier domains via phosphopantetheinyl elimination reactions during tandem mass spectrometry." Biochemistry, 2006, 45 p. 12756-66
17042494
PMC2518290
Garneau-Tsodikova S., Dorrestein P., Kelleher N., Walsh C. "Protein assembly line components in prodigiosin biosynthesis: characterization of PigA,G,H,I,J." J Am Chem Soc, 2006, 128 p. 12600-1
17002325
Chan Y., Boyne M., Podevels A., Klimowicz A., Handelsman J., Kelleher N., Thomas M. "Hydroxymalonyl-acyl carrier protein (ACP) and aminomalonyl-ACP are two additional type I polyketide synthase extender units." Proc Natl Acad Sci U S A, 2006, 103 p. 14349-54
16983083
PMC1599966
Romanova E., Roth M., Rubakhin S., Jakubowski J., Kelley W., Kirk M., Kelleher N., Sweedler J. "Identification and characterization of homologues of vertebrate beta-thymosin in the marine mollusk Aplysia californica." J Mass Spectrom, 2006, 41 p. 1030-40
16924592
Dorrestein P., Van Lanen S., Li W., Zhao C., Deng Z., Shen B., Kelleher N. "The bifunctional glyceryl transferase/phosphatase OzmB belonging to the HAD superfamily that diverts 1,3-bisphosphoglycerate into polyketide biosynthesis." J Am Chem Soc, 2006, 128 p. 10386-7
16895402
Van Lanen S., Lin S., Dorrestein P., Kelleher N., Shen B. "Substrate specificity of the adenylation enzyme SgcC1 involved in the biosynthesis of the enediyne antitumor antibiotic C-1027." J Biol Chem, 2006, 281 p. 29633-40
16887797
Garcia B., Joshi S., Thomas C., Chitta R., Diaz R., Busby S., Andrews P., Ogorzalek Loo R., Shabanowitz J., Kelleher N., Mizzen C., Allis C., Hunt D. "Comprehensive phosphoprotein analysis of linker histone H1 from Tetrahymena thermophila." Mol Cell Proteomics, 2006, 5 p. 1593-609
16835217
Hicks L., Balibar C., Walsh C., Kelleher N., Hillson N. "Probing intra- versus interchain kinetic preferences of L-Thr acylation on dimeric VibF with mass spectrometry." Biophys J, 2006, 91 p. 2609-19
16815901
PMC1562378
Pesavento J., Mizzen C., Kelleher N. "Quantitative analysis of modified proteins and their positional isomers by tandem mass spectrometry: human histone H4." Anal Chem, 2006, 78 p. 4271-80
16808433
Calderone C., Kowtoniuk W., Kelleher N., Walsh C., Dorrestein P. "Convergence of isoprene and polyketide biosynthetic machinery: isoprenyl-S-carrier proteins in the pksX pathway of Bacillus subtilis." Proc Natl Acad Sci U S A, 2006, 103 p. 8977-82
16757561
PMC1482551
Hicks L., Mazur M., Miller L., Dorrestein P., Schnarr N., Khosla C., Kelleher N. "Investigating nonribosomal peptide and polyketide biosynthesis by direct detection of intermediates on >70 kDa polypeptides by using Fourier-transform mass spectrometry." Chembiochem, 2006, 7 p. 904-7
16642537
Howarth M., Chinnapen D., Gerrow K., Dorrestein P., Grandy M., Kelleher N., El-Husseini A., Ting A. "A monovalent streptavidin with a single femtomolar biotin binding site." Nat Methods, 2006, 3 p. 267-73
16554831
PMC2576293
Gatto G., Boyne M., Kelleher N., Walsh C. "Biosynthesis of pipecolic acid by RapL, a lysine cyclodeaminase encoded in the rapamycin gene cluster." J Am Chem Soc, 2006, 128 p. 3838-47
16536560
Hemp J., Robinson D., Ganesan K., Martinez T., Kelleher N., Gennis R. "Evolutionary migration of a post-translationally modified active-site residue in the proton-pumping heme-copper oxygen reductases." Biochemistry, 2006, 45 p. 15405-10
17176062
PMC2535580
Hicks L., Moffitt M., Beer L., Moore B., Kelleher N. "Structural characterization of in vitro and in vivo intermediates on the loading module of microcystin synthetase." ACS Chem Biol, 2006, 1 p. 93-102
17163649
Dorrestein P., Kelleher N. "Dissecting non-ribosomal and polyketide biosynthetic machineries using electrospray ionization Fourier-Transform mass spectrometry." Nat Prod Rep, 2006, 23 p. 893-918
17119639

2005

Thomas P., Foster G. "Tracking acidic pharmaceuticals, caffeine, and triclosan through the wastewater treatment process." Environ Toxicol Chem, 2005, 24 p. 25-30
15683164
Dorrestein P., Yeh E., Garneau-Tsodikova S., Kelleher N., Walsh C. "Dichlorination of a pyrrolyl-S-carrier protein by FADH2-dependent halogenase PltA during pyoluteorin biosynthesis." Proc Natl Acad Sci U S A, 2005, 102 p. 13843-8
16162666
PMC1236592
Kelleher N., Hicks L. "Contemporary mass spectrometry for the direct detection of enzyme intermediates." Curr Opin Chem Biol, 2005, 9 p. 424-30
16129650
Van Lanen S., Dorrestein P., Christenson S., Liu W., Ju J., Kelleher N., Shen B. "Biosynthesis of the beta-amino acid moiety of the enediyne antitumor antibiotic C-1027 featuring beta-amino acyl-S-carrier protein intermediates." J Am Chem Soc, 2005, 127 p. 11594-5
16104723
Frankel B., Kruger R., Robinson D., Kelleher N., McCafferty D. "Staphylococcus aureus sortase transpeptidase SrtA: insight into the kinetic mechanism and evidence for a reverse protonation catalytic mechanism." Biochemistry, 2005, 44 p. 11188-200
16101303
Roth M., Forbes A., Boyne M., Kim Y., Robinson D., Kelleher N. "Precise and parallel characterization of coding polymorphisms, alternative splicing, and modifications in human proteins by mass spectrometry." Mol Cell Proteomics, 2005, 4 p. 1002-8
15863400
PMC1307493
Gatto G., McLoughlin S., Kelleher N., Walsh C. "Elucidating the substrate specificity and condensation domain activity of FkbP, the FK520 pipecolate-incorporating enzyme." Biochemistry, 2005, 44 p. 5993-6002
15835888
Garneau S., Dorrestein P., Kelleher N., Walsh C. "Characterization of the formation of the pyrrole moiety during clorobiocin and coumermycin A1 biosynthesis." Biochemistry, 2005, 44 p. 2770-80
15723521
Chatterjee C., Miller L., Leung Y., Xie L., Yi M., Kelleher N., van der Donk W. "Lacticin 481 synthetase phosphorylates its substrate during lantibiotic production." J Am Chem Soc, 2005, 127 p. 15332-3
16262372
Zabrouskov V., Senko M., Du Y., Leduc R., Kelleher N. "New and automated MSn approaches for top-down identification of modified proteins." J Am Soc Mass Spectrom, 2005, 16 p. 2027-38
16253516
Aron Z., Dorrestein P., Blackhall J., Kelleher N., Walsh C. "Characterization of a new tailoring domain in polyketide biogenesis: the amine transferase domain of MycA in the mycosubtilin gene cluster." J Am Chem Soc, 2005, 127 p. 14986-7
16248612
McLoughlin S., Kelleher N. "Monitoring multiple active sites on thiotemplate enzymes in parallel: a molecular movie of yersiniabactin bioassembly." J Am Chem Soc, 2005, 127 p. 14984-5
16248611
McLoughlin S., Mazur M., Miller L., Yin J., Liu F., Walsh C., Kelleher N. "Chemoenzymatic approaches for streamlined detection of active site modifications on thiotemplate assembly lines using mass spectrometry." Biochemistry, 2005, 44 p. 14159-69
16245932
Yin J., Straight P., McLoughlin S., Zhou Z., Lin A., Golan D., Kelleher N., Kolter R., Walsh C. "Genetically encoded short peptide tag for versatile protein labeling by Sfp phosphopantetheinyl transferase." Proc Natl Acad Sci U S A, 2005, 102 p. 15815-20
16236721
PMC1276090
Miller L., Mazur M., McLoughlin S., Kelleher N. "Parallel interrogation of covalent intermediates in the biosynthesis of gramicidin S using high-resolution mass spectrometry." Protein Sci, 2005, 14 p. 2702-12
16195555
PMC2253301

2004

Thomas P., Foster G. "Determination of nonsteroidal anti-inflammatory drugs, caffeine, and triclosan in wastewater by gas chromatography-mass spectrometry." J Environ Sci Health A Tox Hazard Subst Environ Eng, 2004, 39 p. 1969-78
15332662