Astle J., Ferguson J., German J., Harrigan G., Kelleher N., Kodadek T., Parks B., Roth M., Singletary K., Wenger C., Mahady G. "Characterization of proteomic and metabolomic responses to dietary factors and supplements." J Nutr, 2007, 137 p. 2787-93
Whitteck J., Ni W., Griffin B., Eliot A., Thomas P., Kelleher N., Metcalf W., van der Donk W. "Reassignment of the structure of the antibiotic A53868 reveals an unusual amino dehydrophosphonic acid." Angew Chem Int Ed Engl, 2007, 46 p. 9089-92
Parks B., Jiang L., Thomas P., Wenger C., Roth M., Boyne M., Burke P., Kwast K., Kelleher N. "Top-down proteomics on a chromatographic time scale using linear ion trap fourier transform hybrid mass spectrometers." Anal Chem, 2007, 79 p. 7984-91
Siuti N., Kelleher N. "Decoding protein modifications using top-down mass spectrometry." Nat Methods, 2007, 4 p. 817-21
Hwang Y., Thompson P., Wang L., Jiang L., Kelleher N., Cole P. "A selective chemical probe for coenzyme A-requiring enzymes." Angew Chem Int Ed Engl, 2007, 46 p. 7621-4
Calderone C., Iwig D., Dorrestein P., Kelleher N., Walsh C. "Incorporation of nonmethyl branches by isoprenoid-like logic: multiple beta-alkylation events in the biosynthesis of myxovirescin A1." Chem Biol, 2007, 14 p. 835-46


Tran J., Doucette A. "Cyclic polyamide oligomers extracted from nylon 66 membrane filter disks as a source of contamination in liquid chromatography/mass spectrometry." J Am Soc Mass Spectrom, 2006, 17 p. 652-6
Ricardo A., Frye F., Carrigan M., Tipton J., Powell D., Benner S. "2-Hydroxymethylboronate as a reagent to detect carbohydrates: application to the analysis of the formose reaction." J Org Chem, 2006, 71 p. 9503-5
Dorrestein P., Blackhall J., Straight P., Fischbach M., Garneau-Tsodikova S., Edwards D., McLaughlin S., Lin M., Gerwick W., Kolter R., Walsh C., Kelleher N. "Activity screening of carrier domains within nonribosomal peptide synthetases using complex substrate mixtures and large molecule mass spectrometry." Biochemistry, 2006, 45 p. 1537-46
Boyne M., Pesavento J., Mizzen C., Kelleher N. "Precise characterization of human histones in the H2A gene family by top down mass spectrometry." J Proteome Res, 2006, 5 p. 248-53
Thomas C., Kelleher N., Mizzen C. "Mass spectrometric characterization of human histone H3: a bird's eye view." J Proteome Res, 2006, 5 p. 240-7
Siuti N., Roth M., Mizzen C., Kelleher N., Pesavento J. "Gene-specific characterization of human histone H2B by electron capture dissociation." J Proteome Res, 2006, 5 p. 233-9
Miller L., Chatterjee C., van der Donk W., Kelleher N. "The dehydratase activity of lacticin 481 synthetase is highly processive." J Am Chem Soc, 2006, 128 p. 1420-1
Du Y., Parks B., Sohn S., Kwast K., Kelleher N. "Top-down approaches for measuring expression ratios of intact yeast proteins using Fourier transform mass spectrometry." Anal Chem, 2006, 78 p. 686-94
Patrie S., Ferguson J., Robinson D., Whipple D., Rother M., Metcalf W., Kelleher N. "Top down mass spectrometry of < 60-kDa proteins from Methanosarcina acetivorans using quadrupole FRMS with automated octopole collisionally activated dissociation." Mol Cell Proteomics, 2006, 5 p. 14-25
Woodyer R., Shao Z., Thomas P., Kelleher N., Blodgett J., Metcalf W., van der Donk W., Zhao H. "Heterologous production of fosfomycin and identification of the minimal biosynthetic gene cluster." Chem Biol, 2006, 13 p. 1171-82
McClerren A., Cooper L., Quan C., Thomas P., Kelleher N., van der Donk W. "Discovery and in vitro biosynthesis of haloduracin, a two-component lantibiotic." Proc Natl Acad Sci U S A, 2006, 103 p. 17243-8
Karanam B., Jiang L., Wang L., Kelleher N., Cole P. "Kinetic and mass spectrometric analysis of p300 histone acetyltransferase domain autoacetylation." J Biol Chem, 2006, 281 p. 40292-301
Dorrestein P., Bumpus S., Calderone C., Garneau-Tsodikova S., Aron Z., Straight P., Kolter R., Walsh C., Kelleher N. "Facile detection of acyl and peptidyl intermediates on thiotemplate carrier domains via phosphopantetheinyl elimination reactions during tandem mass spectrometry." Biochemistry, 2006, 45 p. 12756-66
Garneau-Tsodikova S., Dorrestein P., Kelleher N., Walsh C. "Protein assembly line components in prodigiosin biosynthesis: characterization of PigA,G,H,I,J." J Am Chem Soc, 2006, 128 p. 12600-1
Chan Y., Boyne M., Podevels A., Klimowicz A., Handelsman J., Kelleher N., Thomas M. "Hydroxymalonyl-acyl carrier protein (ACP) and aminomalonyl-ACP are two additional type I polyketide synthase extender units." Proc Natl Acad Sci U S A, 2006, 103 p. 14349-54
Romanova E., Roth M., Rubakhin S., Jakubowski J., Kelley W., Kirk M., Kelleher N., Sweedler J. "Identification and characterization of homologues of vertebrate beta-thymosin in the marine mollusk Aplysia californica." J Mass Spectrom, 2006, 41 p. 1030-40
Dorrestein P., Van Lanen S., Li W., Zhao C., Deng Z., Shen B., Kelleher N. "The bifunctional glyceryl transferase/phosphatase OzmB belonging to the HAD superfamily that diverts 1,3-bisphosphoglycerate into polyketide biosynthesis." J Am Chem Soc, 2006, 128 p. 10386-7
Van Lanen S., Lin S., Dorrestein P., Kelleher N., Shen B. "Substrate specificity of the adenylation enzyme SgcC1 involved in the biosynthesis of the enediyne antitumor antibiotic C-1027." J Biol Chem, 2006, 281 p. 29633-40
Garcia B., Joshi S., Thomas C., Chitta R., Diaz R., Busby S., Andrews P., Ogorzalek Loo R., Shabanowitz J., Kelleher N., Mizzen C., Allis C., Hunt D. "Comprehensive phosphoprotein analysis of linker histone H1 from Tetrahymena thermophila." Mol Cell Proteomics, 2006, 5 p. 1593-609
Hicks L., Balibar C., Walsh C., Kelleher N., Hillson N. "Probing intra- versus interchain kinetic preferences of L-Thr acylation on dimeric VibF with mass spectrometry." Biophys J, 2006, 91 p. 2609-19
Pesavento J., Mizzen C., Kelleher N. "Quantitative analysis of modified proteins and their positional isomers by tandem mass spectrometry: human histone H4." Anal Chem, 2006, 78 p. 4271-80
Calderone C., Kowtoniuk W., Kelleher N., Walsh C., Dorrestein P. "Convergence of isoprene and polyketide biosynthetic machinery: isoprenyl-S-carrier proteins in the pksX pathway of Bacillus subtilis." Proc Natl Acad Sci U S A, 2006, 103 p. 8977-82
Hicks L., Mazur M., Miller L., Dorrestein P., Schnarr N., Khosla C., Kelleher N. "Investigating nonribosomal peptide and polyketide biosynthesis by direct detection of intermediates on >70 kDa polypeptides by using Fourier-transform mass spectrometry." Chembiochem, 2006, 7 p. 904-7
Howarth M., Chinnapen D., Gerrow K., Dorrestein P., Grandy M., Kelleher N., El-Husseini A., Ting A. "A monovalent streptavidin with a single femtomolar biotin binding site." Nat Methods, 2006, 3 p. 267-73
Gatto G., Boyne M., Kelleher N., Walsh C. "Biosynthesis of pipecolic acid by RapL, a lysine cyclodeaminase encoded in the rapamycin gene cluster." J Am Chem Soc, 2006, 128 p. 3838-47
Hemp J., Robinson D., Ganesan K., Martinez T., Kelleher N., Gennis R. "Evolutionary migration of a post-translationally modified active-site residue in the proton-pumping heme-copper oxygen reductases." Biochemistry, 2006, 45 p. 15405-10
Hicks L., Moffitt M., Beer L., Moore B., Kelleher N. "Structural characterization of in vitro and in vivo intermediates on the loading module of microcystin synthetase." ACS Chem Biol, 2006, 1 p. 93-102
Dorrestein P., Kelleher N. "Dissecting non-ribosomal and polyketide biosynthetic machineries using electrospray ionization Fourier-Transform mass spectrometry." Nat Prod Rep, 2006, 23 p. 893-918


Thomas P., Foster G. "Tracking acidic pharmaceuticals, caffeine, and triclosan through the wastewater treatment process." Environ Toxicol Chem, 2005, 24 p. 25-30
Dorrestein P., Yeh E., Garneau-Tsodikova S., Kelleher N., Walsh C. "Dichlorination of a pyrrolyl-S-carrier protein by FADH2-dependent halogenase PltA during pyoluteorin biosynthesis." Proc Natl Acad Sci U S A, 2005, 102 p. 13843-8
Kelleher N., Hicks L. "Contemporary mass spectrometry for the direct detection of enzyme intermediates." Curr Opin Chem Biol, 2005, 9 p. 424-30
Van Lanen S., Dorrestein P., Christenson S., Liu W., Ju J., Kelleher N., Shen B. "Biosynthesis of the beta-amino acid moiety of the enediyne antitumor antibiotic C-1027 featuring beta-amino acyl-S-carrier protein intermediates." J Am Chem Soc, 2005, 127 p. 11594-5
Frankel B., Kruger R., Robinson D., Kelleher N., McCafferty D. "Staphylococcus aureus sortase transpeptidase SrtA: insight into the kinetic mechanism and evidence for a reverse protonation catalytic mechanism." Biochemistry, 2005, 44 p. 11188-200
Roth M., Forbes A., Boyne M., Kim Y., Robinson D., Kelleher N. "Precise and parallel characterization of coding polymorphisms, alternative splicing, and modifications in human proteins by mass spectrometry." Mol Cell Proteomics, 2005, 4 p. 1002-8
Gatto G., McLoughlin S., Kelleher N., Walsh C. "Elucidating the substrate specificity and condensation domain activity of FkbP, the FK520 pipecolate-incorporating enzyme." Biochemistry, 2005, 44 p. 5993-6002
Garneau S., Dorrestein P., Kelleher N., Walsh C. "Characterization of the formation of the pyrrole moiety during clorobiocin and coumermycin A1 biosynthesis." Biochemistry, 2005, 44 p. 2770-80
Chatterjee C., Miller L., Leung Y., Xie L., Yi M., Kelleher N., van der Donk W. "Lacticin 481 synthetase phosphorylates its substrate during lantibiotic production." J Am Chem Soc, 2005, 127 p. 15332-3
Zabrouskov V., Senko M., Du Y., Leduc R., Kelleher N. "New and automated MSn approaches for top-down identification of modified proteins." J Am Soc Mass Spectrom, 2005, 16 p. 2027-38
Aron Z., Dorrestein P., Blackhall J., Kelleher N., Walsh C. "Characterization of a new tailoring domain in polyketide biogenesis: the amine transferase domain of MycA in the mycosubtilin gene cluster." J Am Chem Soc, 2005, 127 p. 14986-7
McLoughlin S., Kelleher N. "Monitoring multiple active sites on thiotemplate enzymes in parallel: a molecular movie of yersiniabactin bioassembly." J Am Chem Soc, 2005, 127 p. 14984-5
McLoughlin S., Mazur M., Miller L., Yin J., Liu F., Walsh C., Kelleher N. "Chemoenzymatic approaches for streamlined detection of active site modifications on thiotemplate assembly lines using mass spectrometry." Biochemistry, 2005, 44 p. 14159-69
Yin J., Straight P., McLoughlin S., Zhou Z., Lin A., Golan D., Kelleher N., Kolter R., Walsh C. "Genetically encoded short peptide tag for versatile protein labeling by Sfp phosphopantetheinyl transferase." Proc Natl Acad Sci U S A, 2005, 102 p. 15815-20
Miller L., Mazur M., McLoughlin S., Kelleher N. "Parallel interrogation of covalent intermediates in the biosynthesis of gramicidin S using high-resolution mass spectrometry." Protein Sci, 2005, 14 p. 2702-12


Thomas P., Foster G. "Determination of nonsteroidal anti-inflammatory drugs, caffeine, and triclosan in wastewater by gas chromatography-mass spectrometry." J Environ Sci Health A Tox Hazard Subst Environ Eng, 2004, 39 p. 1969-78