Publications
2006
"Activity screening of carrier domains within nonribosomal peptide synthetases using complex substrate mixtures and large molecule mass spectrometry."
Biochemistry, 2006, 45 p. 1537-46
"Precise characterization of human histones in the H2A gene family by top down mass spectrometry."
J Proteome Res, 2006, 5 p. 248-53
"Mass spectrometric characterization of human histone H3: a bird's eye view."
J Proteome Res, 2006, 5 p. 240-7
"Gene-specific characterization of human histone H2B by electron capture dissociation."
J Proteome Res, 2006, 5 p. 233-9
"The dehydratase activity of lacticin 481 synthetase is highly processive."
J Am Chem Soc, 2006, 128 p. 1420-1
"Top-down approaches for measuring expression ratios of intact yeast proteins using Fourier transform mass spectrometry."
Anal Chem, 2006, 78 p. 686-94
"Top down mass spectrometry of < 60-kDa proteins from Methanosarcina acetivorans using quadrupole FRMS with automated octopole collisionally activated dissociation."
Mol Cell Proteomics, 2006, 5 p. 14-25
"Heterologous production of fosfomycin and identification of the minimal biosynthetic gene cluster."
Chem Biol, 2006, 13 p. 1171-82
"Discovery and in vitro biosynthesis of haloduracin, a two-component lantibiotic."
Proc Natl Acad Sci U S A, 2006, 103 p. 17243-8
"Kinetic and mass spectrometric analysis of p300 histone acetyltransferase domain autoacetylation."
J Biol Chem, 2006, 281 p. 40292-301
"Facile detection of acyl and peptidyl intermediates on thiotemplate carrier domains via phosphopantetheinyl elimination reactions during tandem mass spectrometry."
Biochemistry, 2006, 45 p. 12756-66
"Protein assembly line components in prodigiosin biosynthesis: characterization of PigA,G,H,I,J."
J Am Chem Soc, 2006, 128 p. 12600-1
"Hydroxymalonyl-acyl carrier protein (ACP) and aminomalonyl-ACP are two additional type I polyketide synthase extender units."
Proc Natl Acad Sci U S A, 2006, 103 p. 14349-54
"Identification and characterization of homologues of vertebrate beta-thymosin in the marine mollusk Aplysia californica."
J Mass Spectrom, 2006, 41 p. 1030-40
"The bifunctional glyceryl transferase/phosphatase OzmB belonging to the HAD superfamily that diverts 1,3-bisphosphoglycerate into polyketide biosynthesis."
J Am Chem Soc, 2006, 128 p. 10386-7
"Substrate specificity of the adenylation enzyme SgcC1 involved in the biosynthesis of the enediyne antitumor antibiotic C-1027."
J Biol Chem, 2006, 281 p. 29633-40
"Comprehensive phosphoprotein analysis of linker histone H1 from Tetrahymena thermophila."
Mol Cell Proteomics, 2006, 5 p. 1593-609
"Probing intra- versus interchain kinetic preferences of L-Thr acylation on dimeric VibF with mass spectrometry."
Biophys J, 2006, 91 p. 2609-19
"Quantitative analysis of modified proteins and their positional isomers by tandem mass spectrometry: human histone H4."
Anal Chem, 2006, 78 p. 4271-80
"Convergence of isoprene and polyketide biosynthetic machinery: isoprenyl-S-carrier proteins in the pksX pathway of Bacillus subtilis."
Proc Natl Acad Sci U S A, 2006, 103 p. 8977-82
"Investigating nonribosomal peptide and polyketide biosynthesis by direct detection of intermediates on >70 kDa polypeptides by using Fourier-transform mass spectrometry."
Chembiochem, 2006, 7 p. 904-7
"A monovalent streptavidin with a single femtomolar biotin binding site."
Nat Methods, 2006, 3 p. 267-73
"Biosynthesis of pipecolic acid by RapL, a lysine cyclodeaminase encoded in the rapamycin gene cluster."
J Am Chem Soc, 2006, 128 p. 3838-47
"Evolutionary migration of a post-translationally modified active-site residue in the proton-pumping heme-copper oxygen reductases."
Biochemistry, 2006, 45 p. 15405-10
"Structural characterization of in vitro and in vivo intermediates on the loading module of microcystin synthetase."
ACS Chem Biol, 2006, 1 p. 93-102
"Dissecting non-ribosomal and polyketide biosynthetic machineries using electrospray ionization Fourier-Transform mass spectrometry."
Nat Prod Rep, 2006, 23 p. 893-918
2005
"Tracking acidic pharmaceuticals, caffeine, and triclosan through the wastewater treatment process."
Environ Toxicol Chem, 2005, 24 p. 25-30
"Dichlorination of a pyrrolyl-S-carrier protein by FADH2-dependent halogenase PltA during pyoluteorin biosynthesis."
Proc Natl Acad Sci U S A, 2005, 102 p. 13843-8
"Contemporary mass spectrometry for the direct detection of enzyme intermediates."
Curr Opin Chem Biol, 2005, 9 p. 424-30
"Biosynthesis of the beta-amino acid moiety of the enediyne antitumor antibiotic C-1027 featuring beta-amino acyl-S-carrier protein intermediates."
J Am Chem Soc, 2005, 127 p. 11594-5
"Staphylococcus aureus sortase transpeptidase SrtA: insight into the kinetic mechanism and evidence for a reverse protonation catalytic mechanism."
Biochemistry, 2005, 44 p. 11188-200
"Precise and parallel characterization of coding polymorphisms, alternative splicing, and modifications in human proteins by mass spectrometry."
Mol Cell Proteomics, 2005, 4 p. 1002-8
"Elucidating the substrate specificity and condensation domain activity of FkbP, the FK520 pipecolate-incorporating enzyme."
Biochemistry, 2005, 44 p. 5993-6002
"Characterization of the formation of the pyrrole moiety during clorobiocin and coumermycin A1 biosynthesis."
Biochemistry, 2005, 44 p. 2770-80
"Lacticin 481 synthetase phosphorylates its substrate during lantibiotic production."
J Am Chem Soc, 2005, 127 p. 15332-3
"New and automated MSn approaches for top-down identification of modified proteins."
J Am Soc Mass Spectrom, 2005, 16 p. 2027-38
"Characterization of a new tailoring domain in polyketide biogenesis: the amine transferase domain of MycA in the mycosubtilin gene cluster."
J Am Chem Soc, 2005, 127 p. 14986-7
"Monitoring multiple active sites on thiotemplate enzymes in parallel: a molecular movie of yersiniabactin bioassembly."
J Am Chem Soc, 2005, 127 p. 14984-5
"Chemoenzymatic approaches for streamlined detection of active site modifications on thiotemplate assembly lines using mass spectrometry."
Biochemistry, 2005, 44 p. 14159-69
"Genetically encoded short peptide tag for versatile protein labeling by Sfp phosphopantetheinyl transferase."
Proc Natl Acad Sci U S A, 2005, 102 p. 15815-20
"Parallel interrogation of covalent intermediates in the biosynthesis of gramicidin S using high-resolution mass spectrometry."
Protein Sci, 2005, 14 p. 2702-12
2004
"Determination of nonsteroidal anti-inflammatory drugs, caffeine, and triclosan in wastewater by gas chromatography-mass spectrometry."
J Environ Sci Health A Tox Hazard Subst Environ Eng, 2004, 39 p. 1969-78
"Molecular-level description of proteins from saccharomyces cerevisiae using quadrupole FT hybrid mass spectrometry for top down proteomics."
Anal Chem, 2004, 76 p. 2852-8
"Mass spectrometric interrogation of thioester-bound intermediates in the initial stages of epothilone biosynthesis."
Chem Biol, 2004, 11 p. 327-35
"Shotgun annotation of histone modifications: a new approach for streamlined characterization of proteins by top down mass spectrometry."
J Am Chem Soc, 2004, 126 p. 3386-7
"Targeted analysis and discovery of posttranslational modifications in proteins from methanogenic archaea by top-down MS."
Proc Natl Acad Sci U S A, 2004, 101 p. 2678-83
"Lacticin 481: in vitro reconstitution of lantibiotic synthetase activity."
Science, 2004, 303 p. 679-81
"Role of the active site cysteine of DpgA, a bacterial type III polyketide synthase."
Biochemistry, 2004, 43 p. 970-80
"Kinetic and regiospecific interrogation of covalent intermediates in the nonribosomal peptide synthesis of yersiniabactin."
J Am Chem Soc, 2004, 126 p. 13265-75
