Our Team

Neil
Kelleher

Neil Kelleher
Office:Silverman Hall, Room 3613, Evanston
Phone:(847) 467-4362
Director, Proteomics Center of Excellence
Professor of Molecular Biosciences, Chemistry and the Feinberg School of Medicine

After finishing his joint graduate work with Tadhg Begley and Fred McLafferty at Cornell University in 1997, Neil Kelleher moved to the laboratory of Christopher Walsh at Harvard Medical School.  This training in high performance mass spectrometry and enzymology explains much of the research performed by his independent laboratory over the last decade at the University of Illinois in Urbana-Champaign.  In 2010 the Kelleher Group relocated to Northwestern University where the three main sub-groups continue working in the areas of Top Down Proteomics, Natural Products Biosynthesis/Discovery, and Chromatin Biology.  Dr. Kelleher has been successful in driving both technology development and applications of very high performance mass spectrometry in both chemistry and biology. He has about 150 publications, an H-factor of 39, and provides ProSight software via the web to over 500 labs around the world.  The core of the Kelleher Team is built around expertise in technology development for complex mixture analysis using Fourier-Transform Mass Spectrometry for targeted applications in proteomics and metabolomics.  Dr. Kelleher harbors specific interests in the biosynthesis and discovery of polyketides and non-ribosomally produced peptides.  Further themes of the Kelleher laboratory include using intact proteins for efficient detection of their post-translational modifications, with specific interests in chromatin and cancer biology.

Paul
Thomas

Paul Thomas
Office:Silverman Hall, Room B550B, Evanston
Phone:(847) 467-1076
Associate Director, Proteomics Center of Excellence
Research Assistant Professor in Molecular Biosciences

Paul Thomas has more than 10 years of experience in mass spectrometry, beginning in 2001 with a summer internship at the Food Composition Laboratory (USDA-ARS) in Beltsville, MD to analyze folates in food products. He completed a B.S./M.S. in Chemistry from George Mason University in Fairfax, VA where he quantitated pharmaceuticals and personal care products (PPCPs) through the wastewater treatment process at several sites in Northern Virginia.  In 2004, he joined Neil Kelleher’s laboratory at the University of Illinois, Urbana-Champaign where his work spanned many subgroups and his projects included the construction of the first 12 Tesla LTQ-FT Ultra mass spectrometer, small molecule natural products research, Top Down Proteomics and various bioinformatics projects among others. After receiving his PhD, he served as the Director of the Center for Top Down Proteomics at UIUC where he managed the software launch of ProSightPC™ 2.0.  In 2010, he moved to Northwestern University and has been establishing the Proteomics Center of Excellence.  Paul currently manages large projects within the Proteomics Center of Excellence.

Philip
Compton

Philip Compton
Office:Pancoe 1123, Evanston
Phone:(847) 467-5623
Director of Instrumentation
Research Assistant Professor in Chemistry

Philip Compton earned his B.S. in Chemistry at the University of Illinois while working for Prof. Neil Kelleher on projects related to instrumentation and epigenetics. In 2006, he began a Ph.D. under the guidance of Prof. Donald Hunt at the University of Virginia. During his graduate career, he innovated the fragmentation technique known as Electron Transfer Dissociation by developing a new ion source and adapting the technique to utilize a new reagent. After graduating in 2009, Phil was hired as the Director of Instrumentation for the PCE and is responsible for the maintenance of the center's 11 mass spectrometers and oversees the development of new mass spectrometric instrumentation.

Ryan
Fellers

Office:Hogan, 4-120, Evanston
Phone:(847) 467-3711
Senior Software Engineer

Ryan Fellers earned both B.S. and M.S. degrees in Computer Science from the University of Illinois at Urbana-Champaign. In 2005, he was granted an assistantship in Dr. Kelleher’s lab and worked on a variety of software projects, primarily the commercial application “ProSight PC”. Ryan worked outside of academia for the next 6 years, gaining programming experience and exposure to the latest technologies (.NET 4.0, etc). He returned to proteomics in 2011 with his current position of Senior Software Engineer and is responsible for modernizing the group’s source code and providing a direction for all things software related.

Ioanna
Ntai

Office:Silverman Hall, Room 3735, Evanston
Phone:(847) 467-1354
Senior Research Associate

Ioanna Ntai earned her B.S. in Chemistry at the University of South Alabama, where she synthesized and characterized novel ionic liquids. In 2003, she began her Ph.D in Chemistry at Vanderbilt University under the supervision of Professor Brian Bachmann. Her thesis research focused on the application of mass spectrometry methods for the study of biosynthetic pathways. During her graduate work, Ioanna designed and executed the synthesis of a small peptide natural product and analogues for SAR studies, developed MRM methods for the quantitation of secondary metabolites, and purified proteins using various chromatographic techniques and biochemical assays. In June 2008, she joined Professor Neil Kelleher’s group as a postdoctoral researcher. She contributed to the development of a proteomics-based approach for the discovery of natural products and their gene clusters and has implemented this method for the discovery and study of several novel gene clusters. In 2011, she became a member of the PCE, where she has been using top-down and bottom-up approaches for the study of biological systems, such as protein ubiquitination, in vitro protein synthesis, and oocyte maturation.

Archer
Smith IV

Office:Silverman Hall, Room B531, Evanston
Phone:(847) 467-2681
Research Associate

Archer D. Smith IV graduated from the University of Georgia in 1998 with a B.S. in Chemistry. In 2001 he entered the Ph.D. program at the University of Georgia under the direction of Prof. Michael K. Johnson. While in graduate school he studied the biochemical mechanism of Iron-Sulfur assembly using an array of biophysical and analytical techniques. After receiving his Ph.D. in chemistry Archer, accepted a postdoctoral position in Dr. Averil Ma’s laboratory at the University of California at San Francisco. For the next two years at UCSF he focused on anti-inflammatory components of the NF-κB pathway with particular attention to the novel A20 enzyme maintaining both deubiquitination and ubiquitin E3 ligase activity. In 2007 he moved to the UAB Biomedical FT-ICR MS laboratory at the University of Alabama at Birmingham under the direction of Prof. Matthew Renfrow. During his three year appointment at UAB he focused primarily on applying cutting edge techniques in bottom -up mass spectrometry including protein quantitation and identification of post-translational modifications. In January of 2011 he joined the team at NuSep to further develop software for quantitative bottom-up proteomics. After being removed from a mass spectrometer for 10-months he joined the PCE in October of 2011. Currently he is involved in collaborative projects implementing both top-down and bottom-up mass spectrometry in clinical proteomics.

Yupeng
Zheng

Office:Silverman Hall, Room 3734, Evanston
Phone:(847) 467-1050
Research Associate

Lorem ipsum dolor sit amet, consectetur adipisicing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam, quis nostrud exercitation ullamco laboris nisi ut aliquip ex ea commodo consequat. Duis aute irure dolor in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur. Excepteur sint occaecat cupidatat non proident, sunt in culpa qui officia deserunt mollit anim id est laborum.

Emma
Doud

Office:Silverman Hall, Room B550c, Evanston
Phone:(847) 467-2415
Research Associate
Lab Manager

Emma Doud earned B.S. degrees in both Chemistry and Biology at Purdue University, while doing undergraduate research ranging from synthetic chemistry to ecology. In 2005, she began her Ph.D. in Chemistry and Chemical Biology at Harvard University in the labs of Professors Suzanne Walker and Daniel Kahne. Her thesis work focused on the biosynthesis and biochemistry of the potent natural product antibiotic Moenomycin A. During the last two years of her Ph.D. she was also in charge of maintenance and user training on two shared mass spectrometers. After joining the PCE in August, Emma now runs and develops quantitative bottom up LC/MS methods to monitor histone epigenetic marks and assists with both top down and bottom up protein characterization with various collaborators.

Kyunggon
Kim

Office:Silverman Hall, Room 3735, Evanston
Phone:(847) 467-1354
Postdoctoral Research Associate

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Tyler
Zimmerman

Office:Silverman Hall, Room 3734, Evanston
Phone:(847) 467-1050
Postdoctoral Research Associate

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Caroline
DeHart

Office:Silverman Hall, Room B550c, Evanston
Phone:(847) 467-2415
Postdoctoral Research Associate

Lorem ipsum dolor sit amet, consectetur adipisicing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam, quis nostrud exercitation ullamco laboris nisi ut aliquip ex ea commodo consequat. Duis aute irure dolor in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur. Excepteur sint occaecat cupidatat non proident, sunt in culpa qui officia deserunt mollit anim id est laborum.

John
Savaryn

JP Savaryn
Office:Silverman Hall, Room B531, Evanston
Phone:(847) 467-2681
Postdoctoral Research Staffer

John Paul (JP) earned his B.S. degree from St. Norbert College in 2007 with a major in Biology and a minor in Chemistry. He earned his Ph.D. from the Medical College of Wisconsin in 2012 studying host-pathogen interactions in the laboratory of Dr. Scott Terhune. His Ph.D. thesis work consisted of using a focused proteomics approach to identify protein-protein interactions in multiple biological contexts. In each case, the information was used to uncover novel protein function within the respective context. In the PCE, JP will be working with collaborating labs to make proteomic discoveries relevant to supremely important biological questions.

Bryan
Early

Bryan Early
Office:Hogan, 4-120, Evanston
Phone:(847) 467-3711
Software Engineer

Bryan Early received his BS in Mathematics and Computer Science in 2008 from the University of Illinois, Urbana-Champaign.  During his senior year, he joined the Kelleher Research Group and began work with the ProSightPC software development team.  In 2010, he received a Masters of Science in Mathematics.  He moved to Northwestern University in June 2010.  Bryan's research centers around the development of new algorithms for top down proteomics data analysis.

Joseph
Greer

Office:Hogan, 4-120, Evanston
Phone:(847) 467-3711
Software Engineer

Lorem ipsum dolor sit amet, consectetur adipisicing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam, quis nostrud exercitation ullamco laboris nisi ut aliquip ex ea commodo consequat. Duis aute irure dolor in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur. Excepteur sint occaecat cupidatat non proident, sunt in culpa qui officia deserunt mollit anim id est laborum.

Haylee
Thomas

Haylee Thomas
Office:Silverman Hall, Room 3609, Evanston
Phone:(847) 467-1086
Research Administrator

Haylee Thomas earned her B.A. in Chemistry from Cornell College in Mount Vernon, Iowa in 2004. She went on to earn a M.S. in Chemistry from the University of Illinois Urbana-Champaign in 2009. While at UIUC she studied Top Down proteomics in the Kelleher lab with a focus on the Top Down analysis of the apoptotic proteome of HeLa. Since moving with the Kelleher lab to Northwestern, Haylee has taken on the role of research administrator for the PCE.