Orbitrap Velos Pro
Building on the industry-leading Thermo Scientific Orbitrap platform, the Thermo Scientific Orbitrap Velos Pro hybrid ion trap-Orbitrap mass spectrometer features dual-pressure linear ion trap technology that delivers increased sensitivity and dynamic range with ultimate robustness. With the Thermo Scientific Velos Produal-pressure linear ion trap front end, rapid scanning enables higher productivity and Generation II optics with neutral blocking technology provide enhanced ruggedness for the system. The outstanding high-resolution, accurate-mass (HR/AM) data quality and sensitivity of the Orbitrap Velos Pro™ system, whether using CID, HCD or optional ETD fragmentation, makes it ideal for identification of low-level proteins in complex matrices, rapid quantitation of isobarically labeled peptides and structural elucidation of metabolites.
Olsen JV, Schwartz JC, Griep-Raming J, Nielsen ML, Damoc E, Denisov E, Lange O, Remes P, Taylor D, Splendore M, Wouters ER, Senko M, Makarov A, Mann M, Horning S "A dual pressure linear ion trap Orbitrap instrument with very high sequencing speed." Mol Cell Proteomics, 2009, 8(12) p. 2759-69.
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Köcher T, Swart R, Mechtler K "Ultra-high-pressure RPLC hyphenated to an LTQ-Orbitrap Velos reveals a linear relation between peak capacity and number of identified peptides." Anal Chem, 2011, 83(7) p. 2699-704.
Summary | Full Text (DOI)